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NATPARA® is a parathyroid hormone indicated as an adjunct to calcium and vitamin D to control hypocalcemia in patients with hypoparathyroidism. Because of the potential risk of osteosarcoma, NATPARA is recommended only for patients who cannot be well-controlled on calcium supplements and active forms of vitamin D alone. NATPARA was not studied in patients with hypoparathyroidism caused by calcium-sensing receptor mutations. NATPARA was not studied in patients with acute post-surgical hypoparathyroidism.

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NATPARA® is a parathyroid hormone indicated as an adjunct to calcium and vitamin D to control hypocalcemia in patients with hypoparathyroidism. Because of the potential risk of osteosarcoma, NATPARA is recommended only for patients who cannot be well-controlled on calcium supplements and active forms of vitamin D alone. NATPARA was not studied in patients with hypoparathyroidism caused by calcium-sensing receptor mutations. NATPARA was not studied in patients with acute post-surgical hypoparathyroidism.

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Understanding Hypoparathyroidism

Hypoparathyroidism interferes with calcium homeostasis2

Hypoparathyroidism is a complex endocrine disorder characterized by absent or inappropriately low levels of parathyroid hormone (PTH). Compromised endogenous PTH function can lead to hypocalcemia.2-4

Calcium levels can be maintained through interactions that involve endogenous PTH and the bones, kidneys, intestines, and the active form of vitamin D2

Graph of normal PTH function.

Insufficient endogenous PTH can interfere with certain processes of these organs which can lead to2,3:

  • Decreased intestinal calcium absorption due to a decrease in the conversion of vitamin D to its active form
  • Decreased renal reabsorption of calcium
  • Decreased bone turnover
Graph of compromised PTH function.

References: 1. NATPARA [package insert]. Shire Pharmaceuticals, Inc. 2. Shoback D. N Engl J Med. 2008;359(4):391-403. 3. Bilezikian JP, Khan A, Potts JT Jr, et al. J Bone Miner Res. 2011;26(10):2317-2337. 4. Fong J, Khan A. Can Fam Physician. 2012;58(2):158-162.

NATPARA® and the NATPARA Logo® are registered trademarks of Takeda Pharmaceuticals, U.S.A,. Inc.

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© 2023 Takeda Pharmaceuticals U.S.A., Inc., 300 Shire Way, Lexington, MA 02421. 1-877-TAKEDA-7 (1-877-825-3327). All rights reserved. TAKEDA® and the TAKEDA Logo® are registered trademarks of Takeda Pharmaceutical Company Limited.
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